Nonstandard Vendor Import FAQ
What is a Standard Vendor?
The ARC routinely purchases animals for investigators from a number
of approved animal vendors. These include:
Jackson Laboratory - mice
Charles River Laboratory - mice, rats, hamsters, gerbils
Taconic - mice
Harlan - mice, rats, cats
Covance - rabbits
Marshall Farms - dogs, ferrets
LBL - dogs
Hodgins - dogs
Ken Kessler - pigs
Matthew Joseph - goats
NONSTANDARD VENDOR FORM
When do I use the Nonstandard Vendor IMPORT form (NSV-I)?
Nonstandard Vendors are sources not listed above, OR "gift"
animals that are given to an investigator as part of a collaborative
project. The Nonstandard Vendor Import form is completed and submitted
instead of an ARC Requisition to initiate these transfers.
I would like to receive animals from a collaborator. How do
I begin the process?
Complete a Nonstandard Vendor Import Form (NSV-I). The Nonstandard
Vendor form may be found on this web site at Nonstandard
Vendor Import Forms on the IACUC web site or from the
ARC main office.
What do I need to know about international shipments?
Material derived from rodents and other small mammals which have
not been inoculated with, or exposed to, any exotic livestock or
poultry disease agents may be imported without USDA restrictions.
This applies as long as the material was obtained from facilities
that do not work with exotic livestock or poultry disease agents.
A USDA import permit will not be required for live laboratory mammals
if:
1. A health certificate accompanies live mammals and states that
they are clinically healthy; and
2. There is a statement from the shipper/producer indicating that
the animals:
a. have not been exposed to or inoculated with any livestock or
poultry disease agents exotic to the United States; and
b. have not originated from a facility where work with exotic disease
agents affecting livestock or poultry is conducted.
This information must be supplied as ORIGINAL endorsed statements
and made available for review by the USDA Inspector at the port
of arrival. Do not put the documents INSIDE the shipping container.
If the above information is not supplied, the shipment may be subject
to delays. If the animals or their products cannot meet these criteria,
then a USDA import permit may be required. Permit applications may
be obtained by calling the APHIS automated document retrieval system
at (301) 734-4952.
For additional information on international animal importation,
contact:
APHIS - Protecting American Agriculture
Phone (301) 734-7895
Fax (301) 734-8226
http//www.aphis.usda.gov
What information do I need to provide?
Complete the portions of the NSV-I form bordered with heavy black
in the RECIPIENT INFORMATION, SOURCE INFORMATION and HOUSING INFORMATION
sections.
RECIPIENT INFORMATION _______________________PROTOCOL INFORMATION
(FOR ARC USE ONLY)
You must have an approved and activated IACUC protocol and an account
number for shipping and housing charges.
SOURCE INFORMATION
Please provide contact information for your collaborator and your
colleague's animal facility. Request that a health status report
for the source colony be faxed or emailed to the ARC at 216-368-4763.
The name of the RECEIVING PI should appear prominently on the fax
or e-mail.
To prevent possible confusion during the unboxing process, please
note if more than one line of animals will be shipped and whether
the animals are individually identified.
HOUSING INFORMATION
PI OR DESIGNEE MUST BE AVAILABLE ON THE DAY OF
ARRIVAL.
IF UNBOXING INSTRUCTIONS ARE NOT CLEAR, PI WILL BE RESPONSIBLE FOR
UNBOXING
This information helps the ARC determine the type
of quarantine required and assists with planning for housing space
needs. Microisolator housing for rodents is required during the
quarantine period to prevent disease transmission and is recommended
following release from quarantine. Please contact the Training Coordinator
for Orientation and Microisolator Technique training for yourself
and your research staff if needed.
If multiple strains/lines of rodents or individually identified
rodents are being shipped, the ARC recommends that you or a designee
from your lab be present during the receiving process. In any case,
should questions, or problems arise, please indicate a name and
contact telephone number for yourself or a member of your lab.
Unless an exemption is specifically requested, all rodents that
are quarantined for retesting and release and treated during the
quarantine period for fur mites and pinworms using the miticide
dichlorvos in the bedding and the anthelminthics piperizine in the
drinking water or fenbendazole in specially formulated feed. None
of these agents is known to inhibit breeding, gestation or lactation.
If mice are used for experiment during the quarantine period the
potential subclinical effects of these agents should be considered.
More information about this is available from an ARC Veterinarian.
What information should the sending animal facility provide?
The animal facility must fax or e-mail the latest health status
information from the source colony. Test results must be less than
90 days old. The ARC tracks the following agents in mice:
Quarterly: perineal tape test for Syphacia pinworm
fecal float exam for Aspicularis pinworm
skin scrape/fur pluck for mites
Sendaivirus and Mycoplasma pulmonis serology
Mice: PVM, MVM, GDVII, Reo-3, MPV serology
Rats: PVM, KRV, H-1, Reo-3, MPV serology MHV/SDAV,
Annually: Nasopharynngeal and cecal bacteriology
Mice: LCMV, MAD, Ectromelia, K virus, Polyoma virus, MTLV,
EDIM, MCMV, Hantavirus, E. cuniculi, CAR bacillus
Rats: GDVII, LCMV, MAD, Hantavirus, E. cuniculi, CAR bacillus
How is the shipment approved?
Rodents:
Animals with a negative pathogen status are assigned to the Clean
Quarantine Room, EB12J for pinworm and mite testing followed by
retesting and subsequent release if confirmed negative. Rodents
at risk for harboring restricted pathogens are assigned to the Dirty
Quarantine Room, EB06C for subsequent rederivation by embryo transfer
(mice) or hysterectomy (rats).
Nonrodents:
Nonrodents are quarantined in a separate housing room for observation.
What happens when my animals arrive?
If you have requested to be present during the receiving process,
the ARC Receiving Technician will contact you prior to removing
your animals from their shipping containers.
After your animals are unboxed, the ARC office will contact your
laboratory notifying you of the arrival of your animals.
How do my animals get out of quarantine?
Rodents:
Clean Quarantine (EB12J):
Two to three animals should be submitted for nonsurvival retesting.
If possible, request from your collaborator that the extra animals
be included in the shipment. If extra animals are not available,
your animals will remain in EB12J and may be bred to generate pups
for sentinels. While in the quarantine room you are limited to a
maximum of 7 cage spaces.
Use the orange SENTINEL ANIMALS - ARC USE ONLY label to
identify mice in EB12J set aside for testing. The PI's name and
source of the animals should be added to this label:
Dirty Quarantine (EB06C):
Mice in the dirty quarantine room must be rederived by one of the
CWRU transgenic facilities through the process of embryo transfer.
The rederivation process is a nonsurvival procedure for the donor
female. If possible, request from your collaborator that the extra
females be included in the shipment. If extra females are not available,
your animals will remain in E06C and may be bred to generate pups
for rederivation. While in the quarantine room you are limited to
a maximum of 7 cage spaces. Information about the rederivation process
may be found at the following websites:
CWRU-UH Genetics/Pediatrics Transgenic Facility http://knockout.cwru.edu/services/rederivation.html
CWRU School of Medicine Transgenic Core Facility
http://transgenic.cwru.edu/default.htm
Rats imported for establishment of an in-house breeding colony
may be rederived by hysterectomy by ARC Veterinary Services.
Rodents that are not going to be used to establish a breeding colony
may stay in the quarantine room until experimental use.
Nonrodents:
Nonrodents, depending on the source and species are observed for
disease while in quarantine for approximately 1 month. If there
have been no signs of disease during this time, the animals may
be transferred to rooms housing the same species.
How much will a nonstandard vendor shipment cost me?
Clean Quarantine
EB12J Dirty Quarantine
EB06C
Nonstandard Vendor Processing fee: $50.00
Parasite treatment fee: $10.00/cage
Sentinel testing: $260.00
Rederivation: $300.00
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